Category Archives: Undermethylation

My Trich Supplements


March-April 1200mg

May-Aug 15 2400mg

Aug 16 begin 3600mg

Inositol Powder:

Week 5 Aug 3-9 (12 g/day)

Week 6 Aug 10-16 (18g/day) full dose

Methanonine/SAMe+ magnesium, calcium, zinc

SAMe 200mg Aug 14

SAMe 400mg Aug 21

SAMe 400mg + 1000 methanonine Aug 28

SAMe 400mg + 2000 methanonine Sept 7

SAMe 200mg + 3000 methanonine Sept 14

Oct 1: 3000 mg methanonine, no SAMe


Calcium 1000mg (100% daily value)

Magnesium 400mg (100% daily value)

Zinc 15mg (100% daily value)

Probiotic -10 strains, 25 billion organisms

B-6 100 mg (5,000% daily value)

A 10,000IU (200% daily value)

(note: high doses of vitamin A for extended periods of time are harmful and not recommended)

DHA 500mg

EPA 250 mg

Biotin 10,000mcg

C 1,000mg (only 2x/week)

Undermethylation & Trich – what it means for you

Trichotillomania sufferers are believed to be undermethylated.

Undermethylated people tend to be depleted in these 3 neurotransmitters- serotonin, dopamine, and norepinephrine, which all greatly affects one’s mental health.

Most people with depression, oppositional defiant disorder, OCD, bipolar disorder, trichotillomania, or schizophrenia exhibit a genetic abnormality in methylation….. which appears to be central to their illness.

Trichotillomania treatment includes(1) aggressive doses of l-methionine, calcium, magnesium, along with augmenting nutrients zinc, B-6, Inositol, Vitamin A & C and (2) strict avoidance of folic acid, choline, DMAE, and copper supplements.

Aggressive methylation therapy can be very successful, but usually involves a very slow response. Typically, treatment requires about 2 months before the patient before any progress is evident and 6-12 months are required for all of the benefits to be attained.

One way to speed up the process of recovery is to use SAMe supplements in the beginning. Undermethylated patients usually report nice progress after the first week or two. SAMe is quite expensive, and can be gradually replaced by methionine after a couple of months.

Adults typically require 2,000 – 3,000 mg/day of methionine for several months to see good results. Also, augmenting nutrients such as calcium, magnesium, B-6, and zinc are essential.


Most undermethylated persons in the general population tend to be high-achievers and have good mental health.  These people tend to be our doctors, lawyers, corporate executives, professional athletes and scientists who strive for high career accomplishment.  Undermethylation is also more prevalent in college populations and in affluent neighborhoods.

Many individuals diagnosed with mental illnesses have severe undermethylation which is associated with low serotonin activity.  They have a genetic tendency to be very depressed in calcium, magnesium, methionine, and Vitamin B-6 and may have excessive levels of folic acid in nuclei of brain cells.  Undermethylated persons benefit from biomedical therapy to directly correct the underlying problem using methionine, calcium, magnesium, amongst others.

Decide for yourself if you fit into this chemical biotype.  Here is a list of factors associated with undermethylation – 

•  obsessive/compulsive tendencies

•  history of perfectionism

•  seasonal inhalant allergies

•  low tolerance for pain

•  prior diagnosis of OCD or ODD

•  ritualistic behaviors

•  very strong willed

•  slenderness

•  history of competitiveness in sports

•  calm demeanor, but high inner tension

•  frequent headaches

•  family history of high accomplishment

•  delusions (thought disorder)

•  self-motivated during school years

•  poor concentration endurance

•  social isolation

•  addictiveness

•  phobias

•  good response to antihistamines

•  high fluidity (tears, saliva, etc.)

•  good response to SSRI’s

•  very high libido

•  diagnosis of delusional disorder